Quarterly report pursuant to Section 13 or 15(d)

Recent Developments, Liquidity and Management's Plans (Details Narrative)

v3.20.2
Recent Developments, Liquidity and Management's Plans (Details Narrative)
1 Months Ended 3 Months Ended 6 Months Ended
Aug. 13, 2020
USD ($)
$ / shares
shares
Aug. 11, 2020
USD ($)
$ / shares
shares
Jul. 21, 2020
USD ($)
Jul. 20, 2020
USD ($)
$ / shares
shares
May 18, 2020
USD ($)
$ / shares
shares
May 14, 2020
Apr. 30, 2020
USD ($)
Apr. 22, 2020
USD ($)
Apr. 20, 2020
USD ($)
Apr. 16, 2020
USD ($)
$ / shares
shares
Apr. 10, 2020
USD ($)
Apr. 07, 2020
USD ($)
$ / shares
shares
Mar. 24, 2020
USD ($)
$ / shares
shares
Mar. 23, 2020
USD ($)
Dec. 09, 2019
USD ($)
Aug. 11, 2020
USD ($)
$ / shares
shares
Jun. 30, 2020
USD ($)
$ / shares
shares
Mar. 31, 2020
USD ($)
Jun. 30, 2019
USD ($)
Mar. 31, 2019
USD ($)
Jun. 30, 2020
USD ($)
$ / shares
shares
Jun. 30, 2019
USD ($)
Dec. 31, 2019
USD ($)
$ / shares
shares
Dec. 31, 2018
USD ($)
Research and development expenses                                 $ 1,916,161     $ 4,399,218    
Liabilities                                 2,705,590       2,705,590   $ 1,529,765  
Cash and marketable securities                                 11,561,811       11,561,811      
Restricted cash                                 115,094       115,094      
Marketable securities                                 6,856,805       6,856,805      
Net loss                                 (3,628,131) $ (3,538,536) (794,891) $ (916,958) (7,166,667) (1,711,849)    
Working capital                                 15,772,329       15,772,329      
Total shareholders' equity                                 $ 15,972,148 6,817,451 4,314,134 4,965,918 15,972,148 4,314,134 $ 9,355,170 $ 5,833,753
Net cash used in operating activities                                         (3,883,101) (1,610,352)    
Milestone license fees                                         4,375,557      
Sale of stock | shares                   1,043,500   766,667                        
Sale of stock price per share | $ / shares                   $ 4.00   $ 6.00                        
Proceeds from issuance of stock, gross                 $ 250,000     $ 4,600,002                 $ 8,406,927    
Proceeds from issuance of stock, net                   $ 4,174,000   $ 4,086,207                        
Warrants to purchase shares | shares                       61,333                        
Warrants exercise price | $ / shares                       $ 7.50         $ 0.0001       $ 0.0001      
Proceeds from issuance of warrant                             $ 80                  
Securities Purchase Agreement [Member] | May Offering [Member]                                                
Sale of stock | shares         1,366,856                                      
Sale of stock price per share | $ / shares         $ 3.53                                      
Proceeds from issuance of stock, gross         $ 4,825,002                                      
Proceeds from issuance of stock, net         $ 4,320,720                                      
Placement Agent [Member] | May Offering [Member]                                                
Warrants to purchase shares | shares         109,348                                      
Warrants exercise price | $ / shares         $ 4.4125                                      
COVID-19 Vaccine [Member]                                                
Royalty payments, description                           The Company shall also make quarterly royalty payments to Sellers equal to 5% of the net sales of a COVID-19 vaccine or combination product by the Company (the "COVID-19 Vaccine") for a period of five (5) years following the first commercial sale of the COVID-19 Vaccine; provided, that such payment shall be reduced to 3% for any net sales of the COVID-19 Vaccine above $500 million.                    
Series D Convertible Preferred Stock [Member]                                                
Preferred stock, stated value | $ / shares                                 $ 0.01       $ 0.01   $ 0.01  
Conversion of series d convertible preferred shares for common stock, shares | shares                                 (2,776)              
Preferred stock, shares issued | shares                                 208,577       208,577   0  
Preferred stock, shares outstanding | shares                                 208,577       208,577   0  
Net loss                                        
Total shareholders' equity                                 $ 412,982 418,479 $ 412,982
Series C Convertible Preferred Stock [Member]                                                
Preferred stock, stated value | $ / shares                                 $ 4.00       $ 4.00   $ 4.00  
Preferred stock, shares issued | shares                                 0       0   0  
Preferred stock, shares outstanding | shares                                 0       0   0  
Warrants to purchase shares | shares                                 1,043,500       1,043,500      
Warrants exercise price | $ / shares                                 $ 4.00       $ 4.00      
Proceeds from issuance of warrant                                         $ 4,174,000      
Series C Convertible Preferred Stock [Member] | Subsequent Event [Member]                                                
Warrants to purchase shares | shares   891,500   60,000                       891,500                
Warrants exercise price | $ / shares   $ 4.00   $ 4.00                       $ 4.00                
Proceeds from issuance of warrant       $ 240,000                       $ 3,566,000                
Common Stock [Member]                                                
Conversion of series d convertible preferred shares for common stock, shares | shares                                 2,776       2,776      
Net loss                                        
Total shareholders' equity                                 $ 142,330,116 $ 129,743,689 $ 121,699,375 $ 121,574,327 $ 142,330,116 $ 121,699,375 $ 128,920,414 $ 121,554,547
Preferred Stock [Member]                                                
Conversion of series d convertible preferred shares for common stock, shares | shares                                 2,776       2,776      
Membership Interest Purchase Agreement [Member]                                                
Research and development expenses                                 $ 1,142,500              
Portion of cash purchase price returned             $ 83,334                                  
Payment to sellers                           $ 1,000,000                    
Proceeds from initial equity offering                           $ 8,000,000                    
Percentage of payment to sellers on equity offering                           10.00%                    
Additional cash consideration                           $ 10,000,000                    
Achievement of milestone, description                           Upon the achievement of certain milestones, including the completion of a Phase 2 study for a COVID-19 vaccine that meets its primary endpoints, Sellers will be entitled to receive an additional 750,000 shares of our common stock or, in the event we are unable to obtain stockholder approval for the issuance of such shares, 750,000 shares of non-voting preferred stock that are valued following the achievement of such milestones and shall bear a 10% annual dividend (the "Milestone Shares"). Sellers will also be entitled to contingent payments from us of up to $20,750,000 upon the achievement of certain milestones, including the approval of a new drug application by the U.S. Food and Drug Administration ("FDA").                    
Contingent payments upon achievement of certain milestones                 $ 250,000         $ 20,750,000                    
Liabilities                           $ 892,500                    
Payment to sellers upon consummation direct equity offering         $ 684,790                                      
Royalty payments to sellers, percentage                           0.125                    
Membership Interest Purchase Agreement [Member] | Premas Biotech PVT Ltd [Member]                                                
Achievement of milestone, description           The Company and Premas agreed that the fourth milestone under the License Agreement had been satisfied. Due to the achievement of this milestone, Premas is entitled to receive a payment of $1,000,000.                                    
Membership Interest Purchase Agreement [Member] | Cystron Biotech, LLC [Member]                                                
Agreement description                           As consideration for the Membership Interests, the Company delivered to the Sellers: (1) that number of newly issued shares of its common stock equal to 19.9% of the issued and outstanding shares of its common stock and pre-funded warrants as of the date of the MIPA, but, to the extent that the issuance of its common stock would have resulted in any Seller owning in excess of 4.9% of the Company's outstanding common stock, then, at such Seller's election, such Seller received "common stock equivalent" preferred shares with a customary 4.9% blocker (with such common stock and preferred stock collectively referred to as "Common Stock Consideration"), and (2) $1,000,000 in cash. On March 24, 2020 the Company paid $1,000,000 to the Sellers and delivered 411,403 shares of common stock and 211,353 shares of Series D Convertible Preferred Stock with a customary 4.9% blocker, with an aggregate fair market value of $1,233,057, and recorded $2,233,057 as a charge to research and development expense within the Condensed Consolidated Statements of Operations and Comprehensive Loss. On April 22, 2020, Premas, one of the Sellers, returned to us $299,074 representing its portion of the cash purchase price to acquire Cystron. Premas has advised us that these funds were returned temporarily in order for Premas to meet certain regulatory requirements in India.                    
Proceeds from collaborators                           $ 1,000,000                    
Payment to the sellers                           $ 1,000,000                    
Portion of cash purchase price returned               $ 299,074                                
Membership Interest Purchase Agreement [Member] | Cystron Biotech, LLC [Member] | Premas Biotech PVT Ltd [Member]                                                
Achievement of milestone, description                           Upon the achievement of certain developmental milestones by Cystron, Cystron shall pay to Premas a total of up to $2,000,000. On April 16, 2020, the Company paid Premas $500,000 for the achievement of the first two development milestones, of which $250,000 was accrued as research and development expense for the three months ended March 31, 2020.                    
Membership Interest Purchase Agreement [Member] | Cystron Biotech, LLC [Member] | Series D Convertible Preferred Stock [Member]                                                
Number of shares delivered | shares                         211,353                      
Percentage of blocker                         4.90%                      
Fair market value shares delivered                         $ 1,233,057                      
Research and development expenses                         $ 2,233,057                      
Membership Interest Purchase Agreement [Member] | Cystron Biotech, LLC [Member] | Common Stock [Member]                                                
Number of shares delivered | shares                         411,403                      
Fair market value shares delivered                         $ 1,233,057                      
Research and development expenses                         $ 2,233,057                      
Cystron Medical Panel [Member]                                                
Research and development expenses                                 $ 10,274       $ 10,274      
Achievement of milestone, description                     The Cystron Medical Panel and appointed its first member to the panel. Each member shall be compensated with an initial grant of the Company's common stock with an aggregate fair market value of $25,000 and a monthly cash stipend in the initial amount of $2,500                          
Fair market value common stock                     $ 25,000                          
Monthly cash stipend in initial amount                     $ 2,500                          
Certificate of Designation [Member]                                                
Preferred stock, stated value | $ / shares                         $ 0.01                      
Conversion price, per share | $ / shares                         $ 0.01                      
Stock issuance description                         A holder of Preferred Stock will be prohibited from converting Preferred Stock into shares of our common stock if, as a result of such conversion, the holder, together with its affiliates, would own more than 4.99% of the total number of shares of our common stock then issued and outstanding (with such ownership restriction referred to as the "Beneficial Ownership Limitation"). However, any holder may increase or decrease such percentage to any other percentage not in excess of 9.99%, provided that any increase in such percentage shall not be effective until 61 days after such notice to us.                      
August Offering [Member] | Subsequent Event [Member]                                                
Sale of stock price per share | $ / shares $ 5.67                                              
Proceeds from issuance of stock, gross $ 6,847,908 $ 6,178,000                                            
Warrants to purchase shares | shares 96,620                                              
Warrants exercise price | $ / shares $ 7.0875                                              
Aggregate number of shares of common stock issued during period | shares 1,207,744                                              
Warrant expire date Aug. 11, 2025                                              
Consulting Agreement [Member] | Chief Financial Officer [Member] | Subsequent Event [Member]                                                
Consulting appointment description     the Company appointed Mr. Stuart Benson as Chief Financial Officer, effective August 19, 2020, with a term ending June 30, 2021.                                          
Initial retainer fee     $ 7,500                                          
Fixed monthly payment     $ 13,500